MutL Homolog 3 (MLH3) (Middle Region) Peptide
MLH3
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits MLH3
- MLH3 (MutL Homolog 3 (MLH3))
- Protein Region
- Middle Region
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-MLH3 antibody (Catalog #: ARP42403_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- MLH3 (MutL Homolog 3 (MLH3))
- Synonymes
- AV125803 Peptide, BB126472 Peptide, MGC80774 Peptide, MLH3 Peptide, HNPCC7 Peptide, mutL homolog 3 Peptide, mutL homolog 3 L homeolog Peptide, Mlh3 Peptide, mlh3.L Peptide, MLH3 Peptide, mlh3 Peptide
- Sujet
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This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. MLH3 functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Alias Symbols: HNPCC7, MGC138372
Protein Interaction Partner: MLH1,MLH1,MLH3,MSH4,MLH1,MSH4
Protein Size: 1429 - Poids moléculaire
- 161 kDa
- ID gène
- 27030
- NCBI Accession
- NM_014381, NP_055196
- UniProt
- Q2M1Z1
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