NIMA related kinase 3 (NEK3) (N-Term) Peptide
NEK3
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN980602
Aperçu rapide pour NIMA related kinase 3 (NEK3) (N-Term) Peptide (ABIN980602)
Antigène
NEK3
(NIMA related kinase 3 (NEK3))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-NEK3 antibody (Catalog #: ARP49070_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- NEK3 (NIMA related kinase 3 (NEK3))
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Sujet
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NEK3 is a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. It differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase.In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. The protein encoded by this gene is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. However, the encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. Three transcript variants have been found for this gene, but the full-length nature of only two of them has been characterized.
Alias Symbols: HSPK36, MGC29949
Protein Interaction Partner: CSN2,PRLR,VAV2,PRLR,VAV1,VAV2
Protein Size: 506 -
Poids moléculaire
- 58 kDa
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ID gène
- 4752
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NCBI Accession
- NM_002498, NP_002489
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UniProt
- P51956
Antigène
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