Purine Nucleoside Phosphorylase (PNP) (Middle Region) Peptide
PNP
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN980823
Aperçu rapide pour Purine Nucleoside Phosphorylase (PNP) (Middle Region) Peptide (ABIN980823)
Antigène
PNP
(Purine Nucleoside Phosphorylase (PNP))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-NP antibody (Catalog #: ARP48474_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PNP (Purine Nucleoside Phosphorylase (PNP))
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Classe de substances
- Viral Protein
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Sujet
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Defects in NP are the cause of nucleoside phosphorylase deficiency (NP deficiency). It leads to a severe T-cell immunodeficiency with neurologic disorder in children. The specific function of NP is not yet known.This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC117396, MGC125915, MGC125916, PNP, PRO1837, PUNP, NP
Protein Interaction Partner: APLP1,C1orf103,C7orf64,CCDC90B,NCALD,TFAM,TFB2M,TP53,ZHX1,APLP1,C1orf103,C7orf64,CCDC90B,TP53,ZHX1
Protein Size: 289 -
Poids moléculaire
- 32 kDa
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ID gène
- 4860
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NCBI Accession
- NM_000270, NP_000261
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UniProt
- P00491
Antigène
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