Pyruvate Carboxylase (PC) (C-Term) Peptide
PC
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN981417
Aperçu rapide pour Pyruvate Carboxylase (PC) (C-Term) Peptide (ABIN981417)
Antigène
PC
(Pyruvate Carboxylase (PC))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Séquence
- SLPPLDLQAL EKELVDRHGE EVTPEDVLSA AMYPDVFAHF KDFTATFGPL
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-PC Antibody(ARP59606_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PC (Pyruvate Carboxylase (PC))
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Sujet
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This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.
Alias Symbols: PCB
Protein Interaction Partner: GOT2,MDH2,GOT1,MDH2
Protein Size: 1178 -
Poids moléculaire
- 127 kDa
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ID gène
- 5091
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NCBI Accession
- NM_001040716, NP_001035806
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UniProt
- P11498
Antigène
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