Proliferating Cell Nuclear Antigen (PCNA) Peptide
PCNA
Reactivité: Humain
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN981474
Aperçu rapide pour Proliferating Cell Nuclear Antigen (PCNA) Peptide (ABIN981474)
Antigène
PCNA
(Proliferating Cell Nuclear Antigen (PCNA))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-PCNA antibody (Catalog #: AVARP03018_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PCNA (Proliferating Cell Nuclear Antigen (PCNA))
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Sujet
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PCNA is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
Alias Symbols: MGC8367
Protein Interaction Partner: APEX2,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CDKN1A,DDX17,DNMT1,DSCC1,EXO1,FEN1,FEN1,FEN1,GADD45A,GADD45A,GADD45A,GADD45A,GADD45B,GADD45B,GADD45G,LIG1,MSH3,MSH6,MUTYH,MYBBP1A,NONO,PCNA,POLB,POLD1,POLD2,POLD3,POLDIP2,POLE,PRKDC,RFC2,RFC3,RFC5,TCOF1,UNG,BAZ1B,KCTD13,APEX1,APEX2,BAZ1B,CCNB1,CCND1,CCND3,CCNO,CDC25C,CDC6,CDK1,CDK2,CDK5,CDK6,CDKN1A,CDKN1C,CDT1,CHAF1A,CHTF18,CHTF8,DHX9,DNMT1,DNTT,DNTTIP2,DSCC1,EP300,ERCC5,FEN1,GADD45A,GADD45B,GADD45G,HDAC1,HUS1,ING1,KCTD13,LIG1,MCL1,MSH2,MSH3,MSH6,MUTYH,MYBBP1A,PARP1,PCNA,POLB,POLD1,POLD2,POLD3,POLD4,POLDIP2,POLE,POLH,POLI,POLL,POLM,PPP1CA,PRKDC,PTMA,RAD9A,RBBP8,RFC1,RFC2,RFC3,RFC4,RFC5,RPA1,SEC23IP,SUB1,TCOF1,UBB,UNG,WRN,XRCC1,XRCC5,XRCC6,YBX1,AIRE,ANXA2,APEX1,APEX2,CCNA2,CCND1,CCND3,CCNO,CDC25C,CDC6,CDK2,CDK4,CDKN1A,CDKN1C,CDT1,CHAF1A,CHTF18,CLSPN,CUL4A,DDB1,DNMT1,DNTT,EP300,ERCC5,FEN1,GADD45A,GADD45G,Gadd45b,HDAC1,HLTF,HUS1,ING1,KCTD13,KIAA0101,LIG1,MCL1,MSH2,MSH3,MSH6,MUTYH,MYBBP1A,OTUB1,PARP1,PCNA,PMS2,POLD1,POLD2,POLD3,POLDIP2,POLE,POLH,POLL,PRKDC,Polk,RFC1,RFC2,RFC3,RFC4,RFC5,RPA1,RUVBL2,SMARCA4,TIMELESS,UBC,WRN,XRCC1,XRCC5,XRCC6,YBX1
Protein Size: 261 -
Poids moléculaire
- 29 kDa
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ID gène
- 5111
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NCBI Accession
- NM_002592, NP_002583
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UniProt
- P12004
Antigène
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