PDZ Domain Containing 1 (PDZK1) (N-Term) Peptide
PDZK1
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits PDZK1
- PDZK1 (PDZ Domain Containing 1 (PDZK1))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- NSVTLLVLDG DSYEKAVKTR VDLKELGQSQ KEQGLSDNIL SPVMNGGVQT
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-PDZK1 Antibody(ARP41506_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- PDZK1 (PDZ Domain Containing 1 (PDZK1))
- Synonymes
- xpdzk1 Peptide, PDZK1 Peptide, CAP70 Peptide, CLAMP Peptide, NHERF-3 Peptide, NHERF3 Peptide, PDZD1 Peptide, 1700023D20Rik Peptide, 2610507N21Rik Peptide, 4921513F16Rik Peptide, AI267131 Peptide, AI314638 Peptide, AL022680 Peptide, D3Ertd537e Peptide, Pdzd1 Peptide, mPDZK1 Peptide, Clamp Peptide, PDZ domain containing 1 Peptide, PDZ domain containing 1 L homeolog Peptide, PDZK1 Peptide, pdzk1.L Peptide, pdzk1 Peptide, Pdzk1 Peptide
- Sujet
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PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. PDZK1 may play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. PDZK1 may potentiate the CFTR chloride channel activity. It may function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. PDZK1 may be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
Alias Symbols: CAP70, CLAMP, NHERF3, PDZD1, NHERF-3
Protein Interaction Partner: ABCA1,ABCC2,AKAP10,CFTR,CLCN3,GFAP,PDZK1IP1,PEX5,SCARB1,SLC15A2,SLC17A1,SLC22A11,SLC22A12,SLC22A4,SLC22A5,SLC26A6,SLC9A3,SLCO1A2,SSTR5,ABCC2,AKAP10,CFTR,CLCN3,FARP2,GFAP,PDZK1IP1,PEX5,SCARB1,SLC17A1,SLC22A12,SLC22A4,SLC34A3,SLC9A3,SLC9A3R1,SLC9A3R2,SLK,UB
Protein Size: 519 - Poids moléculaire
- 57 kDa
- ID gène
- 5174
- NCBI Accession
- NM_002614, NP_002605
- UniProt
- Q5T2W1
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