Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (N-Term) Peptide
Aperçu rapide pour Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (N-Term) Peptide (ABIN981770)
Antigène
Origine
Source
Application
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Protein Region
- N-Term
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Séquence
- RPSGNSSSGG KNGQGEPARV RCSHLLVKHS QSRRPSSWRQ EKITRTKEEA
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-PIN1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
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Sujet
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Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
Alias Symbols: DOD, UBL5
Protein Interaction Partner: CCND1,CDC27,PKMYT1,PLK1,RAF1,TP73,TP73,APP,BCL2,CCNB1,CCNE1,CDC25C,CDC27,CDK1,CDK9,CHPF,CSNK2A1,CSNK2A2,CSNK2B,CTNNB1,DAB2,DDX24,FASLG,GGA2,GPAA1,GPHN,JUN,KIF20B,KLHL20,LEPR,MAPT,MDFI,MTFR1,NCOA3,NEK6,NFATC2,NONO,PKMYT1,PLK1,POLR2A,PTOV1,PTPN1,RAB4A,RAF1,
Protein Size: 163 -
Poids moléculaire
- 18 kDa
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ID gène
- 5300
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NCBI Accession
- NM_006221, NP_006212
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UniProt
- Q13526
Antigène
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