Paired-Like Homeodomain 2 (PITX2) (N-Term) Peptide
PITX2
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits PITX2
- PITX2 (Paired-Like Homeodomain 2 (PITX2))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-PITX2 antibody (Catalog #: ARP32432_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- PITX2 (Paired-Like Homeodomain 2 (PITX2))
- Synonymes
- ARP1 Peptide, Brx1 Peptide, IDG2 Peptide, IGDS Peptide, IGDS2 Peptide, IHG2 Peptide, IRID2 Peptide, Otlx2 Peptide, PTX2 Peptide, RGS Peptide, RIEG Peptide, RIEG1 Peptide, RS Peptide, 9430085M16Rik Peptide, Brx1a Peptide, Brx1b Peptide, Munc30 Peptide, Pitx2a Peptide, Pitx2b Peptide, Pitx2c Peptide, Pitx2cbeta Peptide, Ptx2 Peptide, Rieg Peptide, pitx2a Peptide, pitx2c Peptide, zgc:110508 Peptide, XPtx2b Peptide, xPtx2 Peptide, xpitx2 Peptide, arp1 Peptide, brx1 Peptide, idg2 Peptide, igds Peptide, igds2 Peptide, ihg2 Peptide, irid2 Peptide, otlx2 Peptide, pitx2-A Peptide, ptx2 Peptide, rgs Peptide, rieg Peptide, rieg1 Peptide, pitx-2 Peptide, pitx2 Peptide, paired like homeodomain 2 Peptide, paired-like homeodomain transcription factor 2 Peptide, paired-like homeodomain 2 Peptide, paired like homeodomain 2 S homeolog Peptide, paired like homeodomain 2 L homeolog Peptide, PITX2 Peptide, Pitx2 Peptide, pitx2 Peptide, pitx2.S Peptide, pitx2.L Peptide
- Sujet
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The PITX2 gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS), and sporadic cases of Peters anomaly. This protein is involved in the development of the eye, tooth and abdominal organs. It also acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, MGC111022, MGC20144, Otlx2, PTX2, RGS, RIEG, RIEG1, RS
Protein Interaction Partner: CTNNB1,HDAC1,KAT5,LEF1,PDLIM1,PITX2,PROP1,HERC5,MSX2,PITX2,Pou1f1,TRIM25
Protein Size: 317 - Poids moléculaire
- 35 kDa
- ID gène
- 5308
- NCBI Accession
- NM_153426, NP_700475
- UniProt
- Q99697
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