Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) (Middle Region) Peptide

PLOD2 Reactivité: Humain Hôte: Synthetic BP, WB, IHC
N° du produit ABIN981868
  • Antigène Tous les produits PLOD2
    PLOD2 (Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2))
    Protein Region
    Middle Region
    Origine
    Humain
    Source
    • 2
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
    Attributs du produit
    This is a synthetic peptide designed for use in combination with anti-PLOD2 antibody (Catalog #: ARP42731_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Indications d'application
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Antigène
    PLOD2 (Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2))
    Synonymes
    D530025C14Rik Peptide, LH2 Peptide, Plod-2 Peptide, TLH Peptide, procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 Peptide, procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 Peptide, Plod2 Peptide, PLOD2 Peptide
    Sujet
    PLOD2 forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

    Alias Symbols: LH2, TLH

    Protein Interaction Partner: PLOD2,HNRNPA1,PLOD2,RUVBL2

    Protein Size: 758
    Poids moléculaire
    84 kDa
    ID gène
    5352
    NCBI Accession
    NM_182943, NP_891988
Vous êtes ici:
Support technique