Polymerase (DNA Directed) kappa (POLK) Peptide
POLK
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN981954
Aperçu rapide pour Polymerase (DNA Directed) kappa (POLK) Peptide (ABIN981954)
Antigène
POLK
(Polymerase (DNA Directed) kappa (POLK))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-POLK antibody (Catalog #: ARP48793_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- POLK (Polymerase (DNA Directed) kappa (POLK))
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Sujet
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POLK belongs to the DNA polymerase type-Y family. It contains 2 Rad18-type zinc fingers and 1 umuC domain. POLK is a DNA polymerase specifically involved in DNA repair. It plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. It lacks 3'-5' proofreading exonuclease activity. POLK forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
Alias Symbols: DINB1, DINP, POLQ
Protein Interaction Partner: REV1,REV1
Protein Size: 870 -
Poids moléculaire
- 99 kDa
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ID gène
- 51426
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NCBI Accession
- NM_016218, NP_057302
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UniProt
- Q9UBT6
Antigène
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