Poly-U Binding Splicing Factor 60KDa (PUF60) Peptide
PUF60
Reactivité: Humain
Hôte: Synthetic
BP, IHC, WB
N° du produit ABIN982472
Aperçu rapide pour Poly-U Binding Splicing Factor 60KDa (PUF60) Peptide (ABIN982472)
Antigène
PUF60
(Poly-U Binding Splicing Factor 60KDa (PUF60))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-PUF60 antibody (Catalog #: ARP40759_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PUF60 (Poly-U Binding Splicing Factor 60KDa (PUF60))
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Sujet
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PUF60 is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription.The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.
Alias Symbols: FIR, FLJ31379, RoBPI, SIAHBP1
Protein Interaction Partner: CD101,CHD3,FUBP1,LOH12CR1,PCBP1,PPP1R16A,PUF60,SAP30BP,SRSF11,U2AF2,VIM,YWHAG,CD2BP2,CHD3,DDX3X,ELAC2,EWSR1,G3BP1,GPN1,HNRNPA3,HNRNPC,HNRNPL,IGF2BP1,IGF2BP2,IGF2BP3,ILK,KHSRP,LOH12CR1,MOV10,OLA1,P4HB,PABPC1,PABPC4,PPP1R16A,PUF60,RNMTL1,RNPS1,SAP30BP,SARS2,SF3A2,SF3A3,SF3B1,SRSF11,SSB,STOM,SYNCRIP,TROVE2,TTN,U2AF2,UGP2,VIM
Protein Size: 542 -
Poids moléculaire
- 58 kDa
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ID gène
- 22827
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NCBI Accession
- NM_014281, NP_055096
Antigène
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