RAB8A, Member RAS Oncogene Family (RAB8A) (Middle Region) Peptide
RAB8A
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN982580
Aperçu rapide pour RAB8A, Member RAS Oncogene Family (RAB8A) (Middle Region) Peptide (ABIN982580)
Antigène
RAB8A
(RAB8A, Member RAS Oncogene Family (RAB8A))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-RAB8A antibody (Catalog #: AVARP13076_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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RAB8A, Member RAS Oncogene Family (RAB8A) peptide
RAB8A Reactivité: Humain, Boeuf (Vache), Chien Hôte: Synthetic BP, Imm
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))
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Sujet
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RAB8A is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable.The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97 % , 96 %, and 51 % similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MEL, RAB8
Protein Interaction Partner: OPTN,RAB3IP,BAT3,GDI2,MAP4K2,OCRL,OPTN,PDE6D,PQBP1,RAB3IP,RABIF,RIMS2,RPH3A,RPH3AL,SYTL4,BAT3,GDI2,MAP4K2,OPTN,RAB10,RIMS2,RPH3A,RPH3AL,SYTL4
Protein Size: 207 -
Poids moléculaire
- 24 kDa
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ID gène
- 4218
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NCBI Accession
- NM_005370, NP_005361
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UniProt
- P61006
Antigène
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