Runt-Related Transcription Factor 1 (RUNX1) (Middle Region) Peptide
RUNX1
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN983320
Aperçu rapide pour Runt-Related Transcription Factor 1 (RUNX1) (Middle Region) Peptide (ABIN983320)
Antigène
RUNX1
(Runt-Related Transcription Factor 1 (RUNX1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-RUNX1 antibody (Catalog #: P100746_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))
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Sujet
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Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. RUNX1 is the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with severaltypes of leukemia. Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: AML1, AML1-EVI-1, AMLCR1, CBFA2, EVI-1, PEBP2aB
Protein Interaction Partner: CBFB,TLE1,CBFB,TLE1,AR,CBFA2T2,CBFA2T3,CBFB,CCND1,CCND2,CCND3,CDK6,CEBPA,CEBPB,ELF2,ELF4,EP300,FOS,FOXP3,HIPK1,HIPK2,JUN,MYST3,MYST4,NCOR2,PAX5,SUV39H1,TLE1,TLE2,WWTR1,YAP1,AES,CBFA2T2,CBFB,CEBPB,EFNA2,ELF2,ELF4,ETS1,FHL2,FOS,JUN,LEF1,MYOD1,MYST4,PAX5,SMAD1,SMAD2,SMAD3,SMAD5,SUV39H1,TLE1,TRAF6,VDR,YAP1
Protein Size: 453 -
Poids moléculaire
- 49 kDa
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ID gène
- 861
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NCBI Accession
- NM_001001890, NP_001001890
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UniProt
- Q01196
Antigène
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