Suppressor of Cytokine Signaling 7 (SOCS7) (N-Term) Peptide
SOCS7
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN984229
Aperçu rapide pour Suppressor of Cytokine Signaling 7 (SOCS7) (N-Term) Peptide (ABIN984229)
Antigène
SOCS7
(Suppressor of Cytokine Signaling 7 (SOCS7))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-SOCS7 antibody (Catalog #: ARP53700_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))
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Sujet
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SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: NAP4, NCKAP4
Protein Interaction Partner: EGFR,GRB2,IRS2,IRS4,NCK1,PIK3R1,PIK3R2,PLCG1,SORBS3,TUBA1A,TUBB2C,NCK1
Protein Size: 581 -
Poids moléculaire
- 64 kDa
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ID gène
- 30837
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NCBI Accession
- NM_014598, NP_055413
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UniProt
- O14512
Antigène
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