Sperm Associated Antigen 6 (SPAG6) (Middle Region) Peptide
SPAG6
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN984310
Aperçu rapide pour Sperm Associated Antigen 6 (SPAG6) (Middle Region) Peptide (ABIN984310)
Antigène
SPAG6
(Sperm Associated Antigen 6 (SPAG6))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-SPAG6 antibody (Catalog #: ARP53681_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SPAG6 (Sperm Associated Antigen 6 (SPAG6))
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Sujet
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SPAG6 is important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.
Alias Symbols: DKFZp434I153, MGC26276, Repro-SA-1, pf16
Protein Interaction Partner: SPAG16
Protein Size: 509 -
Poids moléculaire
- 56 kDa
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ID gène
- 9576
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NCBI Accession
- NM_012443, NP_036575
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UniProt
- O75602
Antigène
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