Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Peptide
STAT1
Reactivité: Humain
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN984525
Aperçu rapide pour Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Peptide (ABIN984525)
Antigène
STAT1
(Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-STAT1 antibody (Catalog #: ARP38933_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
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Sujet
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STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: DKFZp686B04100, ISGF-3, STAT91, CANDF7
Protein Interaction Partner: CREBBP,GNB2L1,KIT,NMI,STAT1,STAT1,SYK,CREBBP,EP300,GNB2L1,NMI,SYK,ADRA1B,AKT1,BMX,BRCA1,CAMK2D,CAMK2G,CCR1,CCR5,CREBBP,CSE1L,CSF2RB,CXCR4,DUSP3,EGFR,EIF1AD,EIF2AK2,ELP2,EP300,FADD,FANCC,FGFR3,FGFR4,FOS,FYN,GNB2L1,GTF2I,HSF1,IFNAR2,IFNGR1,IL27RA,IL2RB,IL2RG,IRF1,IRF2,IRF9,JAK1,JAK2,JUN,KDR,KIT,KPNA1,KPNA6,LCK,LMO2,MAPK14,MCM3,MCM5,MDK,NMI,PDGFRA,PDGFRB,PIAS1,PRKCD,PRMT1,PTK2,PTPN11,PTPN2,RAC1,RELA,RPS6KA5,SRC,STAT1,STAT2,STAT3,STAT5A,STAT5B,SUMO4,SYK,TNFRSF1A,TNFRSF1B,TRADD,TYK2,UBE2I,VDR,XPO1,ZNF467,BRCA1,C20orf185,CREBBP,EGFR,EIF1AD,EIF2AK2,ELP2,EP300,FANCC,GNB2L1,GTF2I,HSF1,IFNAR2,IL27RA,IL2RB,IRF1,IRF9,JUN,KIT,KPNA1,KPNA2,LMO2,MCM5,MTOR,NMI,PIAS1,PRKCD,PTK2,RNF11,SRC,STAT1,STAT2,STAT2,STAT3,TNFRSF1A,TRADD,TYK2,VDR
Protein Size: 750 -
Poids moléculaire
- 87 kDa
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ID gène
- 6772
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NCBI Accession
- NM_007315, NP_009330
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UniProt
- P42224
Antigène
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