Staufen Double-Stranded RNA Binding Protein 1 (STAU1) Peptide
STAU1
Reactivité: Humain
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN984541
Aperçu rapide pour Staufen Double-Stranded RNA Binding Protein 1 (STAU1) Peptide (ABIN984541)
Antigène
STAU1/Staufen (STAU1)
(Staufen Double-Stranded RNA Binding Protein 1 (STAU1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-STAU1 antibody (Catalog #: ARP40537_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- STAU1/Staufen (STAU1) (Staufen Double-Stranded RNA Binding Protein 1 (STAU1))
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Sujet
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STAU1(Staufen) is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.
Alias Symbols: STAU
Protein Interaction Partner: ARF1,CASC3,NCBP1,PAICS,UPF1,CASC3,CDC42,DHX9,DYNC1I1,FMR1,HNRNPU,INA,IQGAP1,KIF2B,MAP1B,MAPT,MYH1,NCBP1,NCL,PABPC1,PABPN1,PPP1CA,RAC1,RASA1,ROCK2,RPL28,RPL6,RPL7A,RPLP0,RPS6,STAU1,TUBB,TUBB4,UPF1,Rrp1b
Protein Size: 577 -
Poids moléculaire
- 63 kDa
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ID gène
- 6780
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NCBI Accession
- NM_017453, NP_059347
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UniProt
- O95793
Antigène
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