Tyrosyl-DNA Phosphodiesterase 1 (TDP1) (Middle Region) Peptide
TDP1
Reactivité: Souris
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits TDP1
- TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
- Protein Region
- Middle Region
- Origine
- Souris
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- ETNVYLIGST PGRFQGSHRD NWGHFRLRKL LQAHAPSTPK GECWPIVGQF
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-Tdp1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
- Synonymes
- 2810481F14Rik Peptide, 4921509N21Rik Peptide, AI838772 Peptide, AW493413 Peptide, E430034L06Rik Peptide, MLZ-501 Peptide, SCAN1 Peptide, tdp1 Peptide, MGC83708 Peptide, TDP1 Peptide, F8M21.60 Peptide, F8M21_60 Peptide, tyrosyl-DNA phosphodiesterase 1 Peptide, tyrosyl-DNA phosphodiesterase 1 Peptide, tyrosyl-DNA Phosphodiesterase (Tdp1) Peptide, tyrosyl-DNA phosphodiesterase 1 L homeolog Peptide, tyrosyl-DNA phosphodiesterase-like protein Peptide, TDP1 Peptide, Tc00.1047053511191.10 Peptide, Tdp1 Peptide, tdp1.L Peptide, tdp1 Peptide, PTRG_11198 Peptide, MCYG_02121 Peptide, MGYG_03035 Peptide
- Sujet
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Tdp1 is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. It hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. It acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. It has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. It has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Alias Symbols: 2810481F14Rik, 4921509N21Rik, AI838772, AW493413, E430034L06Rik, SCAN1, MLZ-501
Protein Size: 579 - Poids moléculaire
- 64 kDa
- ID gène
- 104884
- NCBI Accession
- NM_028354, NP_082630
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