Thyroid Hormone Receptor, beta (THRB) (N-Term) Peptide
THRB
Reactivité: Humain
Hôte: Synthetic
BP, WB, ChIP
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- Antigène Tous les produits THRB
- THRB (Thyroid Hormone Receptor, beta (THRB))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-THRB antibody (Catalog #: ARP37994_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Thyroid Hormone Receptor, beta (THRB) peptide
THRB Reactivité: Poisson zèbre (Danio rerio) Hôte: Synthetic BP, Imm
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- THRB (Thyroid Hormone Receptor, beta (THRB))
- Synonymes
- C-ERBA-2 Peptide, C-ERBA-BETA Peptide, ERBA2 Peptide, GRTH Peptide, NR1A2 Peptide, PRTH Peptide, THR1 Peptide, THRB1 Peptide, THRB2 Peptide, Nr1a2 Peptide, T3R[b] Peptide, T3Rbeta Peptide, Thrb1 Peptide, Thrb2 Peptide, c-erbAbeta Peptide, TR-beta Peptide, TR[b]1 Peptide, fj24f03 Peptide, trb Peptide, wu:fj24f03 Peptide, CTR BETA 2 Peptide, TR-BETA Peptide, LOC734147 Peptide, thrb Peptide, THRB Peptide, C-erba-beta Peptide, RATT3REC Peptide, T3rec Peptide, TRbeta Peptide, THR Peptide, TRbeta1 Peptide, thyroid hormone receptor beta Peptide, thyroid hormone receptor, beta Peptide, thyroid hormone receptor, beta S homeolog Peptide, thyroid hormone receptor, beta L homeolog Peptide, THRB Peptide, Thrb Peptide, thrb Peptide, thrb.S Peptide, thrb.L Peptide
- Sujet
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THRB is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been determined so far. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Alias Symbols: ERBA-BETA, ERBA2, GRTH, MGC126109, MGC126110, NR1A2, THR1, THRB1, THRB2, PRTH, C-ERBA-2, C-ERBA-BETA
Protein Interaction Partner: ANP32A,BTG1,CTCF,MED21,MPG,NCOA1,NCOA2,NCOA3,NCOA3,PRMT2,RXRB,ACVR1,BRD8,BTG1,C1D,CAMK2B,CCND1,CNOT1,COPS2,CTCF,ESR1,FOXO1,HDAC2,HMGN3,JMJD1C,MECR,MED1,MED21,MPG,NCOA1,NCOA2,NCOA3,NCOA6,NCOR1,NCOR2,NR2F6,NRBF2,NRIP1,PPARGC1A,PRMT2,PSMC3IP,PSMC5,RXRA,RXRB,RXRG,THRB,TP53,TRIP10,TRIP12,TRIP13,TRIP4,TRIP6,ZNHIT3,BRD8,CCND1,COPS2,EIF3I,Hdac2,NCOA1,NCOA2,NCOA6,NCOR2,NR2F6,NRBF2,PPARGC1A,PPARGC1B,PRMT1,PSMC5,RXRA,SRC,TBL1X,THRB,TP53,TRIP4,TSG101
Protein Size: 461 - Poids moléculaire
- 53 kDa
- ID gène
- 7068
- NCBI Accession
- NM_000461, NP_000452
- UniProt
- P10828
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