Ubiquitin Protein Ligase E3A (ube3a) (N-Term) Peptide
ube3a
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN985847
150,78 €
Plus frais de livraison 40,00 € et TVA
100 μg
Destination:
France
Envoi sous 15 à 21 jours ouvrables
Aperçu rapide pour Ubiquitin Protein Ligase E3A (ube3a) (N-Term) Peptide (ABIN985847)
Antigène
ube3a
(Ubiquitin Protein Ligase E3A (ube3a))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-UBE3A antibody (Catalog #: ARP42950_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ube3a (Ubiquitin Protein Ligase E3A (ube3a))
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Sujet
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UBE3A is an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
Alias Symbols: ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A
Protein Interaction Partner: UBE2L3,UBE2L6,AR,BLK,BPY2B,BPY2C,BPY2C,EAPP,MCM7,PGR,PHF17,RARA,SCAMP1,SHBG,SMAD9,TP53,UBE2D1,UBE2D3,UBE2E1,UBE2G1,UBE2G2,UBE2L3,UBE2L6,UBE3A,UBQLN2,BARD1,BLK,BPY2,BRCA1,ESR2,LCK,MCM7,PGR,TSC2,UBE2D1,UBE2D2,UBE2D3,UBE2L3,UBQLN1,UBQLN2
Protein Size: 875 -
Poids moléculaire
- 101 kDa
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ID gène
- 7337
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NCBI Accession
- NM_000462, NP_000453
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UniProt
- Q05086
Antigène
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