PHGDH Produits
(phosphoglycerate Dehydrogenase (PHGDH))
Catégories
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011].
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Catégories PHGDH en vedette
PHGDH Anticorps
High quality antibodies with extensive validation data.
PHGDH Kits ELISA
Reliable ELISA kits for a wide range of species.
PHGDH Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PHGDH recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p), IF, IP
Validations
- (1)
- (10)
N° du produit
ABIN565240
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p), IF, IP, IHC (fro), ICC
Validations
- (6)
N° du produit
ABIN2855237
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, IP
Validations
- (5)
N° du produit
ABIN6145554
Quantité
100 μL
Fiche technique
Fiche technique
PHGDH recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
N° du produit
ABIN6969482
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Various Species
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN2815100
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6951683
Quantité
96 tests
Fiche technique
Fiche technique
PHGDH recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1314910
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7124414
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
- (1)
N° du produit
ABIN3076848
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits PHGDH
: "Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 24, Issue 21, pp. 5392-5406, (2018) (PubMed).: "Systematic analysis of mRNA expression profiles in NSCLC cell lines to screen metastasis-related genes." dans: Molecular medicine reports, Vol. 14, Issue 6, pp. 5093-5103, (2017) (PubMed).
: "PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis." dans: Cancer research, Vol. 76, Issue 15, pp. 4430-42, (2016) (PubMed).
: "An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation." dans: Cancer & metabolism, Vol. 3, pp. 5, (2015) (PubMed).
: "Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability." dans: Nucleic acids research, Vol. 43, Issue 7, pp. 3667-79, (2015) (PubMed).
: "NRF2 regulates serine biosynthesis in non-small cell lung cancer." dans: Nature genetics, Vol. 47, Issue 12, pp. 1475-81, (2015) (PubMed).
: "Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells." dans: Nature, Vol. 493, Issue 7433, pp. 542-6, (2013) (PubMed).
: "Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis." dans: PLoS genetics, Vol. 8, Issue 3, pp. e1002573, (2012) (PubMed).
: "Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. ..." dans: Nature, Vol. 476, Issue 7360, pp. 346-50, (2011) (PubMed).
: "Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis." dans: Breast cancer research and treatment, Vol. 125, Issue 2, pp. 421-30, (2010) (PubMed).
Synonymes et noms alternatifs relatifs à PHGDH
phosphoglycerate dehydrogenase (phgdh), D-3-phosphoglycerate dehydrogenase (EDA9), D-3-phosphoglycerate dehydrogenase (serA), D-3-phosphoglycerate dehydrogenase (Sthe_2284), D-3-phosphoglycerate dehydrogenase (Dacet_1260), D-3-phosphoglycerate dehydrogenase (Mrub_0173), phosphoglycerate dehydrogenase (MMAH_RS07650), D-3-phosphoglycerate dehydrogenase (Arnit_0487), D-3-phosphoglycerate dehydrogenase (Ndas_0174), D-3-phosphoglycerate dehydrogenase (Mesil_2386), D-3-phosphoglycerate dehydrogenase (Slip_0010), D-3-phosphoglycerate dehydrogenase (Trad_0302), D-3-phosphoglycerate dehydrogenase (Acear_0027), D-3-phosphoglycerate dehydrogenase (Mahau_0665), phosphoglycerate dehydrogenase (MZHIL_RS05165), D-3-phosphoglycerate dehydrogenase (Mesop_1331), D-3-phosphoglycerate dehydrogenase (Thein_0855), 3-phosphoglycerate dehydrogenase (Phgdh), phosphoglycerate dehydrogenase (PHGDH), phosphoglycerate dehydrogenase (Phgdh), 3-PGDH, 3PGDH, 4930479N23, A10, ECK2909, embryo sac development arrest 9, F10M10.7, fb38f06, JW2880, PDG, PGAD, PGD, PGDH, SERA, wu:fb38f06, zgc:65956Protein level used designations for PHGDH
- D-3-phosphoglycerate dehydrogenase
- 3-phosphoglycerate dehyrogenase
- 3-phosphoglycerate dehydrogenase
- 3-PGDH
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