PI3K p85a/g/b anticorps (AA 465-469)
Cité dans 2 publications.
Cet anticorps anti-PI3K p85a/g/b Polyclonal Lapin (ABIN363076) détecte spécifiquement PI3K p85a/g/b dans IHC.
L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.
(2 références)
N° du produit ABIN363076
378,40 €
Plus frais de livraison 40,00 € et TVA
Destination:
France
Envoi sous 10 à 14 jours ouvrables
Aperçu rapide pour PI3K p85a/g/b anticorps (AA 465-469) (ABIN363076)
Antigène
PI3K p85a/g/b
(Phosphoinositide 3 Kinase, p85 alpha/gamma/beta (PI3K p85a/g/b))
Reactivité
Humain, Souris, Rat
Hôte
Lapin
Clonalité
Polyclonal
Application
Immunohistochemistry (IHC)
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Épitope
- AA 465-469
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Specificité
- The antibody detects endogenous level of total PI3K P85 a/g/b protein.
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Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
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Immunogène
- Peptide sequence around AA 465-469, 197-201, 462-466 (L-Y-E-E-Y) derived from Human PI3K P85. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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Isotype
- IgG
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Indications d'application
- Immunohistochemistry: 1:50-1:100
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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: "Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells." dans: Lipids in health and disease, Vol. 12, pp. 83, (2013) (PubMed).
: "The "HER2-PI3K/Akt-FASN Axis" regulated malignant phenotype of colorectal cancer cells." dans: Lipids, Vol. 47, Issue 4, pp. 403-11, (2012) (PubMed).
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- PI3K p85a/g/b (Phosphoinositide 3 Kinase, p85 alpha/gamma/beta (PI3K p85a/g/b))
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Autre désignation
- PI3K P85 alpha/gamma/beta
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Sujet
- PI3K binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
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Poids moléculaire
- 85 kDa
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UniProt
- O00459
Antigène
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