PNKP Produits
(Polynucleotide Kinase 3'-Phosphatase (PNKP))
Catégories
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010].
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Catégories PNKP en vedette
PNKP Anticorps
High quality antibodies with extensive validation data.
PNKP Kits ELISA
Reliable ELISA kits for a wide range of species.
PNKP Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PNKP recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (1)
- (8)
N° du produit
ABIN6145836
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (7)
N° du produit
ABIN7262583
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (5)
N° du produit
ABIN564910
Quantité
50 μL
Fiche technique
Fiche technique
PNKP recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1123845
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1123846
Quantité
96 tests
Fiche technique
Fiche technique
PNKP recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1315550
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1315552
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
N° du produit
ABIN3086075
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits PNKP
: "MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas." dans: Cancer discovery, Vol. 9, Issue 4, pp. 526-545, (2019) (PubMed).: "Mechanism for recycling tRNAs on stalled ribosomes." dans: Nature structural & molecular biology, Vol. 26, Issue 5, pp. 343-349, (2019) (PubMed).
: "Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription." dans: eLife, Vol. 8, (2019) (PubMed).
: "In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer. ..." dans: Nature communications, Vol. 9, Issue 1, pp. 3501, (2018) (PubMed).
: "Quantitative Label-Free Phosphoproteomics Reveals Differentially Regulated Protein Phosphorylation Involved in West Nile Virus-Induced Host Inflammatory Response." dans: Journal of proteome research, Vol. 14, Issue 12, pp. 5157-68, (2016) (PubMed).
: "Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability." dans: Nucleic acids research, Vol. 43, Issue 7, pp. 3667-79, (2015) (PubMed).
: "Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability." dans: The EMBO journal, Vol. 34, Issue 19, pp. 2465-80, (2015) (PubMed).
: "Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage." dans: Nucleic acids research, Vol. 39, Issue 21, pp. 9224-37, (2011) (PubMed).
: "Spectroscopic studies of DNA and ATP binding to human polynucleotide kinase: evidence for a ternary complex." dans: Biochemistry, Vol. 42, Issue 41, pp. 12077-84, (2003) (PubMed).
: "Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining." dans: The EMBO journal, Vol. 21, Issue 11, pp. 2827-32, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à PNKP
polynucleotide kinase 3'-phosphatase (PNKP), polynucleotide kinase 3'-phosphatase (Pnkp), polynucleotide kinase 3'-phosphatase (Tc00.1047053507017.50), polynucleotide kinase 3'-phosphatase (Tc00.1047053505807.190), polynucleotide kinase 3'-phosphatase (Tb927.6.1580), polynucleotide kinase 3'-phosphatase (BBOV_IV000690), polynucleotide kinase 3'-phosphatase (CC1G_05202), hypothetical protein (PGTG_20262), hypothetical protein (PGTG_18987), polynucleotide kinase 3'-phosphatase (pnkp.S), polynucleotide kinase 3'-phosphatase (pnkp), polynucleotide kinase 3'- phosphatase (Pnkp), 21.m03011, 1810009G08Rik, EIEE10, MCSZ, PNK, Tb06.28P18.320Protein level used designations for PNKP
- DNA 5'-kinase/3'-phosphatase
- Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP)
- bifunctional polynucleotide phosphatase/kinase
- polynucleotide kinase 3'-phosphatase
- polynucleotide kinase-3'-phosphatase
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