POMC Produits
(Proopiomelanocortin (POMC))
Catégories
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
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Catégories POMC en vedette
POMC Anticorps
High quality antibodies with extensive validation data.
POMC Kits ELISA
Reliable ELISA kits for a wide range of species.
POMC Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
POMC recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
- (6)
N° du produit
ABIN185387
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IP
Validations
- (5)
N° du produit
ABIN519039
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (4)
N° du produit
ABIN5542293
Quantité
0.1 mg
Fiche technique
Fiche technique
POMC recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6958845
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969634
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969633
Quantité
96 tests
Fiche technique
Fiche technique
POMC recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1315730
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7124601
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7124600
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits POMC
: "A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes." dans: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 31, Issue 1-2, pp. 17-29, (2020) (PubMed).: "Hindbrain dorsal vagal complex AMPK controls hypothalamic gluco-regulatory transmitter and counter-regulatory hormone responses to hypoglycemia." dans: Brain research bulletin, Vol. 144, pp. 171-179, (2019) (PubMed).
: "Age-dependent decline of hypothalamic HIF2α in response to insulin and its contribution to advanced age-associated metabolic disorders in mice." dans: The Journal of biological chemistry, Vol. 294, Issue 13, pp. 4946-4955, (2019) (PubMed).
: "Hindbrain 5'-Adenosine Monophosphate-activated Protein Kinase Mediates Short-term Food Deprivation Inhibition of the Gonadotropin-releasing Hormone-Luteinizing Hormone Axis: Role of Nitric Oxide." dans: Neuroscience, Vol. 383, pp. 46-59, (2019) (PubMed).
: "Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity." dans: The Journal of clinical investigation, Vol. 128, Issue 3, pp. 1125-1140, (2018) (PubMed).
: "Air-liquid interface enhances oxidative phosphorylation in intestinal epithelial cell line IPEC-J2." dans: Cell death discovery, Vol. 3, pp. 17001, (2017) (PubMed).
: "A potential role for the secretogranin II-derived peptide EM66 in the hypothalamic regulation of feeding behaviour." dans: Journal of neuroendocrinology, Vol. 29, Issue 3, (2017) (PubMed).
: "Early Repeated Administration of CXCR4 Antagonist AMD3100 Dose-Dependently Improves Neuropathic Pain in Rats After L5 Spinal Nerve Ligation." dans: Neurochemical research, Vol. 41, Issue 9, pp. 2289-99, (2016) (PubMed).
: "Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying." dans: BioMed research international, Vol. 2015, pp. 651048, (2016) (PubMed).
: "Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury." dans: Neural regeneration research, Vol. 7, Issue 22, pp. 1729-35, (2015) (PubMed).
Synonymes et noms alternatifs relatifs à POMC
proopiomelanocortin a (pomca), pro-opiomelanocortin-alpha (Pomc), proopiomelanocortin (POMC), proopiomelanocortin (Pomc), ACTH, alpha-MSH, alphaMSH, BE, Beta-LPH, beta-MSH, Clip, CLIP, Gamma-LPH, gamma-MSH, LPH, MSH, Npp, NPP, POC, pomc, Pomc-1, Pomc1, Pomc2, SI:bZ36D5.1, si:bz36d5.2, SI:bZ36D5.4Protein level used designations for POMC
- beta-endorphin
- pro-opiomelanocortin
- adrenal corticotropic hormone
- adrenocorticotropic hormone
- alpha-melanocyte stimulating hormone
- corticotropin-like intermediary peptide
- corticotropin-lipotropin
- melanotropin gamma
- met-enkephalin
- adrenocorticotropin
- alpha-MSH
- alpha-melanocyte-stimulating hormone
- beta-LPH
- beta-MSH
- beta-melanocyte-stimulating hormone
- gamma-LPH
- gamma-MSH
- lipotropin beta
- lipotropin gamma
- melanotropin alpha
- melanotropin beta
- opiomelanocortin prepropeptide
- pro-ACTH-endorphin
- proopiomelanocortin preproprotein
- pro-opiomelanocortin-alpha
- proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
- proopiomelanocortin, beta (endorphin, beta)
- proopoimelanocortin, beta (endorphin, beta)
- Corticotropin-lipotropin
- beta-lipotropin
- beta-melanocyte stimulating hormone
- pro-opiomelanocortin a-1
- pro-opiomelanocortin a-2
- pro-opiomelanocortin b-1
- pro-opiomelanocortin b-2
Avez-vous cherché autre chose?
- POM121L2
- POM121L1P
- POM121L12
- POM121C
- POM121B
- POM121
- Polyubiquitin 3
- Polypyrimidine Tract-Binding Protein
- Polyprotein
- Polymyxin B
- Polychaetoid
- Polybromo 1
- Poly(A) Binding Protein, Nuclear 1-Like (Cytoplasmic)
- Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2
- Poly(A) Binding Protein, Cytoplasmic 1-Like
- Poly(A) Binding Protein, Cytoplasmic 1
- Poly-U Binding Splicing Factor 60KDa
- Poly-ADP-Ribose
- Poly Ubiquitin
- Poly Serum Antigen
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