PRNP Produits
(Prion Protein (PRNP))
Catégories
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].
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Catégories PRNP en vedette
PRNP Anticorps
High quality antibodies with extensive validation data.
PRNP Kits ELISA
Reliable ELISA kits for a wide range of species.
PRNP Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PRNP recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (4)
N° du produit
ABIN7433921
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (4)
N° du produit
ABIN7193415
Quantité
0.1 mg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (3)
N° du produit
ABIN7260569
Quantité
200 μL
Fiche technique
Fiche technique
PRNP recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969500
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969499
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6958725
Quantité
96 tests
Fiche technique
Fiche technique
PRNP recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
N° du produit
ABIN7275480
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN7275481
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1316351
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PRNP
: "Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 4, pp. 5082-5088, (2020) (PubMed).: "Effects of cellular prion protein on rapid eye movement sleep deprivation-induced spatial memory impairment." dans: Journal of integrative neuroscience, Vol. 18, Issue 4, pp. 439-444, (2020) (PubMed).
: "Atypical scrapie in Australia." dans: Australian veterinary journal, Vol. 94, Issue 12, pp. 452-455, (2016) (PubMed).
: "Geno- and phenotyping of human neutrophil antigens." dans: Methods in molecular biology (Clifton, N.J.), Vol. 1310, pp. 193-203, (2016) (PubMed).
: "Allelic variants at codon 146 in the PRNP gene show significant differences in the risk for natural scrapie in Cypriot goats." dans: Epidemiology and infection, Vol. 143, Issue 6, pp. 1304-10, (2015) (PubMed).
: "Polo-like kinase 3 (PLK3) mediates the clearance of the accumulated PrP mutants transiently expressed in cultured cells and pathogenic PrP(Sc) in prion infected cell line via protein interaction." dans: The international journal of biochemistry & cell biology, Vol. 62, pp. 24-35, (2015) (PubMed).
: "Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay." dans: The Journal of biological chemistry, Vol. 290, Issue 27, pp. 17020-8, (2015) (PubMed).
: "The prion protein inhibits monocytic cell migration by stimulating β1 integrin adhesion and uropod formation." dans: Journal of cell science, Vol. 128, Issue 16, pp. 3018-29, (2015) (PubMed).
: "Detection of the GPI-anchorless prion protein fragment PrP226* in human brain." dans: BMC neurology, Vol. 13, pp. 126, (2013) (PubMed).
: "The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6." dans: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37241-55, (2013) (PubMed).
Synonymes et noms alternatifs relatifs à PRNP
prion protein (PRNP), prion protein (Prnp), prion protein S homeolog (prnp.S), prion protein b (prnpb), AA960666, AI325101, AltPrP, ASCR, CD230, CJD, cjd, GSS, KURU, MGC84114, p27-30, prion, PRIP, Prn, Prn-i, Prn-p, PRNP, prnprs1, PrP, prp, PRP, Prp, prp(c), PrP-1, PrP1, PrP27-30, prP27-30, PrP33-35C, prP33-35C, PrPProtein level used designations for PRNP
- CD230 antigen
- major prion protein
- prion-related protein
- prion protein, PrP
- prion protein, structural
- major scrapie-associated fibril protein 1
- prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)
- prion protein PrP
- prion protein precursor PrP
- prion protein variant a
- prion protein variant b
- 65-21 protein
- ARIA
- PR-LP
- acetylcholine receptor-inducing activity
- major prion protein homolog
- prion-like protein
- prion-like-protein
- prion protein
- infectious amyloid
- Major prion protein
- major prion protein preproprotein
- prP
- prP27-30
- prP33-35C
- PrP 27-30
- prion protein 1
- prion protein b
- prion protein, related sequence 1
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