CXCL2 Protein (AA 39-107)

N° du produit ABIN1096467

Cette protéine Recombinant CXCL2 est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour CXCL2 Protein (AA 39-107) (ABIN1096467)

Antigène: CXCL2 (Chemokine (C-X-C Motif) Ligand 2 (CXCL2))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 39-107

Fonction: Recombinant Human C-X-C Motif Chemokine 2/CXCL2

Séquence: MTELRCQCLQ TLQGIHLKNI QSVKVKSPGP HCAQTEVIAT LKNGQKACLN PASPMVKKII EKMLKNGKSN

Attributs du produit: Recombinant Human C-X-C Motif Chemokine 2/CXCL2 is produced with our E. coli expression system. The target protein is expressed with sequence (Thr39-Asn107) of Human CXCL2.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM TrisHCl, 400 mM NaCl, pH 8.5.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 3 months

Détail du antigène

Antigène: CXCL2 (Chemokine (C-X-C Motif) Ligand 2 (CXCL2))

Autre désignation: mip-2

Sujet: Chemokine (C-X-C Motif) Ligand 2 (CXCL2) is a small secreted cytokine which belongs to the CXC chemokine family. CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. CXCL2/MIP2-alpha is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2. CXCL2/MIP2-alpha has been known to regulate immune functions mainly by chemo-attracting neutrophils. It is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is a hematoregulatory chemokine, which suppresses hematopoietic progenitor cell proliferation. CXCL2 can be induced by receptor activator of NF-kappaB ligand, the osteoclast (OC) differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
Alternative Names: C-X-C Motif Chemokine 2, Growth-Regulated Protein Beta, Gro-Beta, Macrophage Inflammatory Protein 2-Alpha, MIP2-Alpha, CXCL2, GRO2, GROB, MIP2A, SCYB2

Poids moléculaire: 7.67 kDa

UniProt: P19875

Pathways: Cellular Response to Molecule of Bacterial Origin