Interleukin 17a Protein (AA 20-155)

N° du produit ABIN1096903

Détail du produit

Antigène: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 20-155

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Functional Studies (Func)

Fonction: Recombinant Human Interleukin-17A/IL-17A

Séquence: MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA

Attributs du produit: ED50 is approximately 2 ng/mL as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts.
Specific Activity of 5 x 10 ⁵ IU/mg.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, pH 7.4.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Autre désignation: Interleukin-17A/IL-17A (IL17A Produits)

Synonymes: CTLA8 Protein, IL-17 Protein, IL-17A Protein, IL17 Protein, Ctla-8 Protein, Ctla8 Protein, Il17 Protein, ChIL-17 Protein, IL-17F Protein, IL17A Protein, CTLA-8 Protein, interleukin 17A Protein, IL17A Protein, Il17a Protein

Sujet: Recombinant Human Interleukin-17A/IL-17A produced in E. coli is a single non-glycosylated polypeptide chain containing 133 AAs with a molecular mass of 15,256 Daltons.
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-α, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

Poids moléculaire: 15.26 kDa

UniProt: Q16552