HFE Protein (His tag)

N° du produit ABIN1098722

Cette protéine Recombinant HFE est produite dans Escherichia coli (E. coli).

Aperçu rapide pour HFE Protein (His tag) (ABIN1098722)

Antigène: HFE (Hemochromatosis (HFE))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Pureté: > 85 % by SDS - PAGE

Détail du produit

Purification/Conjugué: Cette HFE protéine est marqué à la His tag.

Information d'application

Commentaires:

Synonyms: Hereditary hemochromatosis protein, HFE1, HH, HLA-H, MVCD7, TFQTL2

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea, 10% glycerol

Stock: 4 °C

Stockage commentaire: Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: HFE (Hemochromatosis (HFE))

Autre désignation: HFE

Sujet: HFE, also known as HLA-H, belongs to the MHC class I family. This protein contains 1 Ig-like C1-type (immunoglobulin-like) domain. HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta-2 microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor (TFR) with transferrin. It binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. Recombinant human HFE protein, fused to His-tag at N-terminus, was expressed in E.coli.

Poids moléculaire: 35.7kDa (308aa)

NCBI Accession: NP_000401

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process