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Calreticulin 3 Protein (CALR3) (AA 20-384)

CALR3 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
N° du produit ABIN1692465
  • Antigène Voir toutes Calreticulin 3 (CALR3) Protéines
    Calreticulin 3 (CALR3)
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 20-384
    Origine
    • 4
    • 2
    • 1
    • 1
    Humain
    Source
    • 3
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Fonction
    Recombinant Human Calreticulin-3/CALR3/CRT2
    Séquence
    MTVYFQEEFL DGEHWRNRWL QSTNDSRFGH FRLSSGKFYG HKEKDKGLQT TQNGRFYAIS ARFKPFSNKG KTLVIQYTVK HEQKMDCGGG YIKVFPADID QKNLNGKSQY YIMFGPDICG FDIKKVHVIL HFKNKYHENK KLIRCKVDGF THLYTLILRP DLSYDVKIDG QSIESGSIEY DWNLTSLKKE TSPAESKDWE QTKDNKAQDW EKHFLDASTS KQSDWNGDLD GDWPAPMLQK PPYQDGLKPE GIHKDVWLHR KMKNTDYLTQ YDLSEFENIG AIGLELWQVR SGTIFDNFLI TDDEEYADNF GKATWGETKG PEREMDAIQA KEEMKKAREE EEEELLSGKI NRHEHYFNQF HRRNEL
    Attributs du produit
    Recombinant Human calreticulin-3/CALR3/CRT2 is produced with our E. coli expression system. The target protein is expressed with sequence (Thr20-Leu384) of Human CALR3 fused with a 6His tag at the C-terminus.
    Pureté
    > 95 % as determined by reducing SDS-PAGE.
    Stérilité
    0.2 μm filtered
    niveau d'endotoxine
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product CALR3 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
    Conseil sur la manipulation
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Stock
    4 °C/-20 °C/-80 °C
    Stockage commentaire
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Date de péremption
    5 months
  • Antigène
    Calreticulin 3 (CALR3)
    Autre désignation
    CALR3 (CALR3 Produits)
    Synonymes
    1700031L01Rik Protein, 6330586I20Rik Protein, Crt2 Protein, cspn Protein, CMH19 Protein, CRT2 Protein, CT93 Protein, A. thaliana calreticulin 3 Protein, AtCRT3 Protein, CALRETICULIN 3 Protein, EBS2 Protein, EMS-MUTAGENIZED BRI1 SUPPRESSOR 2 Protein, PRIORITY IN SWEET LIFE 1 Protein, PSL1 Protein, T27G7.13 Protein, T27G7_13 Protein, calreticulin 3 Protein, CALR Protein, calreticulin 3 Protein, CALR3 Protein, Calr3 Protein, CRT3 Protein
    Sub Type
    Fusionprotein
    Sujet
    Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19), it is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain.
    Alternative Names: Calreticulin-3, calreticulin-2, calsperin, CALR3, CRT2
    Poids moléculaire
    42.9 kDa
    UniProt
    Q96L12
    Pathways
    Activation of Innate immune Response
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