Myoglobin Protein (MB)
Aperçu rapide pour Myoglobin Protein (MB) (ABIN1880424)
Antigène
Voir toutes Myoglobin (MB) ProtéinesType de proteíne
Activité biologique
Origine
Source
Application
Pureté
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Myoglobin (MB) (AA 2-100) protein (GST tag)
MB Origine: Humain Hôte: Wheat germ Recombinant ELISA, WB, AA, AP
Myoglobin (MB) (AA 1-154) protein (His tag)MB Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 90 % SDS
Myoglobin (MB) (AA 2-154) protein (His tag)MB Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Myoglobin (MB) (AA 2-154) protein (His-IF2DI Tag)MB Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 50 mM Tris-HCl ( pH 8.0), 300 mM NaCl with 0.1 % SKL.
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Stock
- 4 °C
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Stockage commentaire
- Ship at 4°C. Upon receipt, aliquot and store at 2-8°C for long term. Avoid repeated freeze and thaw cycles.
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- Myoglobin (MB)
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Autre désignation
- Myoglobin
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Sujet
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Synonyms: Myoglobin, MB, PVALB
Description: Recombinant full length human Myoglobin protein with molecular weight 17.8 kDa.
Background: Myoglobin, MB is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates in general and in almost all mammals. It is a cytoplasmic hemoprotein, expressed solely in cardiac myocytes and oxidative skeletal muscle fibers, that reversibly binds O2 by its heme residue, a porphyrin ring:iron ion complex. MB is a single-chain globular protein of 153 or 154 amino acids, containing a heme prosthetic group in the center around which the remaining apoprotein folds. Myoglobin is released from damaged muscle tissue (rhabdomyolysis), which has very high concentrations of myoglobin. The released myoglobin is filtered by the kidneys but is toxic to the renal tubular epithelium and so may cause acute renal failure. It is a sensitive marker for muscle injury, making it a potential marker for heart attack in patients with chest pain. However, elevated myoglobin has low specificity for acute myocardial infarction (AMI) and thus CK-MB, cTnT, ECG, and clinical signs should be taken into account to make the diagnosis.
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Poids moléculaire
- 17.8 kDa
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Pathways
- Brown Fat Cell Differentiation
Antigène
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