PRSS2 Protéine

N° du produit ABIN1880447

Cette protéine Recombinant PRSS2 est produite dans Escherichia coli (E. coli).

Aperçu rapide pour PRSS2 Protéine (ABIN1880447)

Antigène: PRSS2 (Protease, serine, 2 (Trypsin 2) (PRSS2))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Application: ELISA, SDS-PAGE (SDS)

Pureté: >96 % by SDS-PAGE

Détail du produit

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Tris-HCl ( pH 7.4±0.2) with 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Shipat 4°C.Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.

Détail du antigène

Antigène: PRSS2 (Protease, serine, 2 (Trypsin 2) (PRSS2))

Autre désignation: Trypsinogen 2

Sujet:

Synonyms: Trypsinogen II, TG2

Description: Recombinant full length human TG2 protein with molecular weight 31 kDa.

Background: Trypsinogen is the precursor form or zymogen of the pancreatic enzyme trypsin. It functions as storage of an inactive form of trypsin so that it may be kept in pancreas and released in significant amount when required for protein digestion. Rowen et al. (1996) found thatonly 2 of 3 pancreatically expressed trypsinogen cDNAs correspond to trypsinogen genes in the TCRB locus, T4 was denoted trypsinogen 1 and T8 was denoted trypsinogen 2. The third pancreatic cDNA, identified independently as trypsinogen 3 and 4, is distinct from the third apparently functional trypsinogen gene (T6) in the TCRB locus but related to the other pancreatic trypsinogens. Teich et al. (2004) demonstrated that the E79K mutation in PRSS1 activated anionic trypsinogen 2-fold better than wildtype cationic trypsin did, whereas the common pancreatitis-associated mutants R122H and N29I had no such effect. The observations not only suggested a novel mechanism of action for pancreatitis-associated trypsinogen mutations, but also highlighted the importance of interactions between the 2 major trypsinogen isoforms in the development of genetically determined chronic pancreatitis.

Poids moléculaire: 31 kDa