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IL-10 Protein (AA 19-178)

IL10 Origine: Humain Hôte: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active
N° du produit ABIN2018051
  • Antigène Voir toutes IL-10 (IL10) Protéines
    IL-10 (IL10) (Interleukin 10 (IL10))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 19-178
    Origine
    • 20
    • 12
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Source
    • 31
    • 22
    • 18
    • 5
    • 2
    CHO Cells
    Attributs du produit
    ED50 < 0.2 ng/mL, measured in a cell proliferation assay using MC/9 cells.
    Pureté
    > 95 % as analyzed by SDS-PAGE and HPLC.
    niveau d'endotoxine
    < 0.2 EU/μg, determined by LAL method.
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    Discover our top product IL10 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstituted in ddH2O or PBS at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Stock
    -80 °C
    Stockage commentaire
    Lyophilized recombinant Human Interleukin-10 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human Interleukin-10 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
    Date de péremption
    6 months
  • Antigène
    IL-10 (IL10) (Interleukin 10 (IL10))
    Autre désignation
    Interleukin-10(IL-10) (IL10 Produits)
    Synonymes
    CSIF Protein, GVHDS Protein, IL-10 Protein, IL10A Protein, TGIF Protein, Il-10 Protein, IL10X Protein, interleukin 10 Protein, IL10 Protein, Il10 Protein
    Sujet
    Interleukin-10 (IL-10), initially known as Cytokine Synthesis Inhibitory Factor (CSIF), belongs to the IL-10 family and shares more than 80 % sequence homology with Epstein-Barr Virus protein BCRFI. It is produced by many immune cells, such as T-cells, macrophages, mast cells, and dendritic cells. It is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and Th2 cells. It also displays ability to suppress Antigen-Presenting Cell (APC) function. The net effect of Interleukin-10 appears to be inhibitory, however, stimulatory effects, such as stimulation of B cell maturation and antibody production, are also reported.
    Synonyms: B-TCGF, CSIF, TGIF
    Poids moléculaire
    18-19 kDa, observed by reducing SDS-PAGE.
    UniProt
    P22301
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints
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