IL-33 Protein (AA 112-270)

N° du produit ABIN2018111

Cette protéine Recombinant IL-33 est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour IL-33 Protein (AA 112-270) (ABIN2018111)

Antigène: IL-33 (IL33) (Interleukin 33 (IL33))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % by SDS-PAGEanalysis.

Détail du produit

Attributs du protein: AA 112-270

Attributs du produit: ED50 <0.5 ng/mL, measured by a cell proliferation assay using D10S cells, corresponding to a specific activity of > 2× 10^6 units/mg.

niveau d'endotoxine: < 0.2 EU/μg, determined by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Stock: -80 °C

Stockage commentaire: Lyophilized recombinant human Interleukin-33 (rhIL-33) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhIL-33 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

Date de péremption: 6 months

Détail du antigène

Antigène: IL-33 (IL33) (Interleukin 33 (IL33))

Autre désignation: Interleukin-33 (IL-33)

Sujet: Interleukin-33 (IL-33) is a proinflammatory cytokine that belongs to the IL-1 family. IL-33 is expressed in a variety of cells, including epithelial and endothelial cells, smooth muscle cells, macrophages and fibroblasts. The primary receptors for IL-33 are ST2 and IL-1 receptor accessory protein (IL-1RAcP), both of which belong to the IL-1 receptor family. IL-33 is localized to the nucleus of resting cells where it binds to chromatin in the H2A-H2B histone complex as a transcriptional suppressor. IL-33 is secreted by cells during injury which induces a T-helper 2 type inflammatory response. Evidence suggests IL-33 plays a role in autoimmune disease. IL-33's interaction with ST2 can drive allergic pathology and IL-33 has been reported to play a role in the development of rheumatoid arthritis and systemic lupus erythematosus.Recombinant humanInterleukin-33 (rhIL-33) produced in E. coli is a single non-glycosylated polypeptide chain containing 159 amino acids. A fully biologically active molecule, rhIL-33 has a molecular mass of 18.0 kDa analyzed by reducing SDS-PAGE.
Synonyms: IL-1F11, NF-HEV

Poids moléculaire: 18.0 kDa, observed by reducing SDS-PAGE.

UniProt: O95760

Pathways: Production of Molecular Mediator of Immune Response