GDF5 Protéine

N° du produit ABIN2468474

Cette protéine Recombinant GDF5 est produite dans Escherichia coli (E. coli).

Aperçu rapide pour GDF5 Protéine (ABIN2468474)

Antigène: GDF5 (Growth Differentiation Factor 5 (GDF5))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: Escherichia coli (E. coli)

Pureté: < 98 % by SDS-PAGE gel and HPLC analyses.

Détail du produit

Séquence: APLANRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR

Attributs du produit: Endotoxin level is less than 0.1 ng per μg (1EU/μg).

niveau d'endotoxine: Endotoxin level is less than 0.1 ng per μg (1 EU/μg).

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Conseil sur la manipulation: As with any protein, exposing GDF-5 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Stock: -20 °C

Stockage commentaire: The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted GDF-5 stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.

Date de péremption: 24 months

Détail du antigène

Antigène: GDF5 (Growth Differentiation Factor 5 (GDF5))

Autre désignation: GDF-5

Sujet: GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 348 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant murine GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids.

ID gène: 8200

NCBI Accession: NP_000548

OMIM: 4503969

UniProt: P43026