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CXCL14 Protein (AA 23-99)

CXCL14 Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant > 98 % , as determined by Coomassie stained SDS-PAGE. FACS Active
N° du produit ABIN2666915
  • Antigène Voir toutes CXCL14 Protéines
    CXCL14 (Chemokine (C-X-C Motif) Ligand 14 (CXCL14))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 23-99
    Origine
    • 7
    • 4
    • 3
    Souris
    Source
    • 13
    • 1
    Escherichia coli (E. coli)
    Application
    Flow Cytometry (FACS)
    Pureté
    > 98 % , as determined by Coomassie stained SDS-PAGE.
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine

    Less than 0.01 ng per μg cytokine as determined by the LAL method.

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    Discover our top product CXCL14 Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    Biological activity: Bioactivity was measured by its property to chemoattract PGE2 activated THP-1 cells in a dose dependent manner.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Reconstitution
    For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 μg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1 % BSA or HSA. After dilution, the cytokine can be stored between 2 °C and 8 °C for one month or from -20 °C to -70 °C for up to 3 months.
    Buffer
    0.22 μm filtered protein solution is in PBS.
    Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    Unopened vial can be stored between 2°C and 8°C for three months, at -20°C for six months, or at -70°C for one year.
  • Antigène
    CXCL14 (Chemokine (C-X-C Motif) Ligand 14 (CXCL14))
    Autre désignation
    CXCL14 (CXCL14 Produits)
    Synonymes
    BMAC Protein, BRAK Protein, KEC Protein, KS1 Protein, MIP-2g Protein, MIP2G Protein, NJAC Protein, SCYB14 Protein, 1110031L23Rik Protein, 1200006I23Rik Protein, AI414372 Protein, Kec Protein, MIP2gamma Protein, Scyb14 Protein, bolekine Protein, scyba Protein, fb67g04 Protein, wu:fb67g04 Protein, JSC Protein, bmac Protein, brak Protein, kec Protein, ks1 Protein, mip-2g Protein, mip2g Protein, njac Protein, scyb14 Protein, CXCL14 Protein, DKFZp469J175 Protein, C-X-C motif chemokine ligand 14 Protein, chemokine (C-X-C motif) ligand 14 Protein, chemokine (C-X-C motif) ligand 14 L homeolog Protein, CXCL14 Protein, Cxcl14 Protein, cxcl14 Protein, cxcl14.L Protein
    Sujet
    Mouse CXCL14 was identified from an EST database of a murine immature keratinocyte cDNA library. mRNA expression in mouse tissues showed high levels in brain, ovary, lung, and muscle. CXCL14 is well conserved between humans, birds, frogs and fish at the amino acid level, and human and mouse CXCL14 share 95 % identity. Original studies showed a decrease in the expression of CXCL14 in head and neck squamous cell carcinoma (HNSCC) and cervical squamous cell carcinoma (SCCs) tumors, and the induction of expression of CXCL14 in human oral carcinoma prevented tumor growth of these cells in vivo. Therefore, it was suggested that CXCL14 possesses tumor suppressing function, and it was speculated that CXCL14 secreted by stromal cells chemoattracts iDCs (immature DCs) and NK cells that activate the immune response against tumor cells. Most recent data showed that epigenetic silencing of CXCL5, CXCL12, and CXCL14 occurs in 75 % of primary lung adenocarcinomas. Consequently, the low expression of CXCL14 in tumors might allow them to escape immune surveillance. Opposite of HNSCC and SCCs tumors, prostate, pancreatic, and colorectal cancers show high expression of CXCL14, inducing growth and invasiveness of pancreatic and breast cancer cells.
    Poids moléculaire
    The 77 amino acid recombinant protein has a predicted molecular mass of approximately 9.5 kDa. The DTT-reduced and non-reduced protein migrate at approximately 13 and 14 kDa by SDS-PAGE respectively. The N-terminal amino acid is Met.
    Pathways
    Autophagy
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