ASH1L Protein (AA 2407-2579) (His tag,DYKDDDDK Tag)

N° du produit ABIN2669693

Détail du produit

Antigène: ASH1L (Ash1 (Absent, Small, Or Homeotic)-like (ASH1L))

Type de proteíne: Recombinant

Attributs du protein: AA 2407-2579

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette ASH1L protéine est marqué à la His tag,DYKDDDDK Tag.

Application: Binding Studies (Bind), Screening Assay (ScA)

Attributs du produit: The peptide corresponding to amino acids 2407-2579 that contains the bromodomain sequences of ASH1L (accession number NP_060959.2) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag with an observed molecular weight of 25.6 kDa.

Information d'application

Indications d'application: Recombinant ASH1L (2407-2579) is suitable for use in binding assays, inhibitor screening, and selectivity profiling.

Restrictions: For Research Use only

Stockage

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.

Détail du antigène

Antigène: ASH1L (Ash1 (Absent, Small, Or Homeotic)-like (ASH1L))

Autre désignation: ASH1L (ASH1L Produits)

Synonymes: ASH1L Protein, fi34d11 Protein, wu:fi34d11 Protein, si:ch211-81a5.3 Protein, Ci-ZF(PHD)-13 Protein, DKFZp468L0923 Protein, ASH1 Protein, ASH1L1 Protein, KMT2H Protein, 8030453L17Rik Protein, Ash1 Protein, E430018P19Rik Protein, Kmt2h Protein, ASH1 like histone lysine methyltransferase Protein, ash1 (absent, small, or homeotic)-like (Drosophila) Protein, absent, small, or homeotic discs 1 homolog Protein, Ash1l protein Protein, Ash1l Protein, ASH1L Protein, ash1l Protein, LOC778906 Protein, CpipJ_CPIJ001203 Protein

Sujet: ASH1L is a member of the Trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. The bromodomain functions as a 'reader' of epigenetic histone marks and regulates chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. ASH1L is localized to the nucleus and also to cell-cell tight junctions where it is hypothesized to function in adhesion-mediated signaling. ASH1L functions in methylation of H3K4 and regulation of expression of HOX genes and may possess methyltransferase activity directed at H3K36. ASH1L has also been implicated in facioscapulohumeral muscular dystrophy.

Poids moléculaire: 25.6 kDa