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DLAT Protein (Myc-DYKDDDDK Tag)

DLAT Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
N° du produit ABIN2719517
  • Antigène Voir toutes DLAT Protéines
    DLAT (Dihydrolipoyl Transacetylase (DLAT))
    Type de proteíne
    Recombinant
    Origine
    • 6
    • 3
    • 1
    Humain
    Source
    • 5
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette DLAT protéine est marqué à la Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Attributs du produit
    • Recombinant human DLAT / DLTA protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Pureté
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product DLAT Protéine
  • Indications d'application
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Commentaires

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Stock
    -80 °C
    Stockage commentaire
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Antigène
    DLAT (Dihydrolipoyl Transacetylase (DLAT))
    Autre désignation
    Dlat,dlta (DLAT Produits)
    Synonymes
    DLAT Protein, Dmel\\CG5261 Protein, EP(2)0816 Protein, EP816 Protein, anon-WO0118547.121 Protein, DLTA Protein, PDC-E2 Protein, PDCE2 Protein, wu:fc14f10 Protein, wu:fc21f08 Protein, wu:fc86g11 Protein, wu:fj57d06 Protein, 6332404G05Rik Protein, midline uncoordinated Protein, dihydrolipoamide S-acetyltransferase L homeolog Protein, dihydrolipoamide S-acetyltransferase Protein, dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) Protein, muc Protein, dlat.L Protein, DLAT Protein, Dlat Protein, dlat Protein
    Sujet
    This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95 % of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009].
    Poids moléculaire
    59.6 kDa
    NCBI Accession
    NP_001922
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