LTA Protein (Transcript Variant 2)

N° du produit ABIN2733938

Détail du produit

Antigène: LTA (Lymphotoxin-alpha (LTA))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: Transcript Variant 2

Origine: Chemical

Source: Escherichia coli (E. coli)

Application: Functional Studies (Func), Protein Interaction (PI), Antibody Production (AbP), Standard (STD)

Specificité: Optimal preservation of protein structure, post-translational modifications and functions.

Attributs du produit:

• Recombinant human TNF-beta / Lymphotoxin-alpha (transcript variant 2) protein expressed in E. coli.
• Produced with end-sequenced ORF clone
• Tested for bioactivity.

Pureté: > 95 % as determined by SDS-PAGE and Coomassie blue staining

niveau d'endotoxine: Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).

Biological Activity Comment: ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin-D is less than or equal to 0.05 ng/ml, corresponding to a specific activity of > 2 x 10^7 units/mg.

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays

Restrictions: For Research Use only

Stockage

Buffer: Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2

Conseil sur la manipulation: Resuspend the protein in the desired concentration in proper buffer

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: LTA (Lymphotoxin-alpha (LTA))

Autre désignation: Tnf-Beta,lymphotoxin-alpha (LTA Produits)

Synonymes: LT Protein, TNFB Protein, TNFSF1 Protein, LT-[a] Protein, LT-alpha Protein, LT[a] Protein, LTalpha Protein, Ltx Protein, TNF-beta Protein, Tnfb Protein, Tnfsf1b Protein, hlb382 Protein, lymphotoxin alpha Protein, lymphotoxin A Protein, LTA Protein, Lta Protein

Classe de substances: Chemical

Sujet: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. [UniProtKB/Swiss-Prot Function]

Poids moléculaire: 18.6 kDa

NCBI Accession: NP_000586

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process