AADAT Protein (His tag)

N° du produit ABIN2745733

Cette protéine Recombinant AADAT est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour AADAT Protein (His tag) (ABIN2745733)

Antigène: AADAT (Aminoadipate Aminotransferase (AADAT))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Pureté: >97 % (SDS-PAGE)

Détail du produit

Purification/Conjugué: Cette AADAT protéine est marqué à la His tag.

Fonction: Kynurenine Aminotransferase II (human) (rec.) (His)

Réactivité croisée: Humain

Attributs du produit: Human full-length KAT II is fused at the N-terminus to a His-tag.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In 50 mM phosphate buffer pH 8.0, containing 50 mM sodium chloride and 40μM pyridoxal 5'-phosphate (PLP).

Conseil sur la manipulation: After opening, prepare aliquots and store at -80 °C. Avoid freeze/thaw cycles.

Stock: -20 °C,-80 °C

Stockage commentaire:

Short Term Storage: -20°C

Long Term Storage: -80°C

Use & Stability: Stable for at least 6 months after receipt when stored at -80°C.

Date de péremption: 6 months

Détail du antigène

Antigène: AADAT (Aminoadipate Aminotransferase (AADAT))

Autre désignation: Kynurenine Aminotransferase II

Sujet:

hKAT II, KAT2, alpha-Aminoadipate Aminotransferase (Mitochondrial), AADAT, EC 2.6.1.7

Kynurenine aminotransferases (KATs) are pyridoxal-5'-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders. Biochemical and structural investigations revealed that L-kynurenine (L-KYN) recognition by hKAT II is achieved by exploiting structural features that are peculiar of this isoform, thus offering the possibility to select/design inhibitor molecules specifically targeting hKAT II to be used as modulators of kynurenic acid synthesis in the CNS. hKAT II is one of the aminotransferases involved in the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of L-kynurenine (L-KYN) to kynurenic acid (KYNA) in the central nervous system. When assayed in vitro the protein also displays beta-elimination activity.

Poids moléculaire: ~49.8kDa