Profilin Protein (PFN) (AA 1-163)

N° du produit ABIN2745816

Cette protéine Recombinant Profilin est produite dans Escherichia coli (E. coli).

Aperçu rapide pour Profilin Protein (PFN) (AA 1-163) (ABIN2745816)

Antigène: Profilin (PFN)

Type de proteíne: Recombinant

Origine: Souris

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Pureté: >95 % (SDS-PAGE)

Détail du produit

Attributs du protein: AA 1-163

Fonction: Profilin (Toxoplasma gondii) (rec.)

Réactivité croisée: Souris

Attributs du produit: Recombinant profilin (Toxoplasma gondii) (aa 1-163).

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with 100 μL sterile water.

Concentration: 0.1 mg/mL

Buffer: Contains PBS.

Conseil sur la manipulation: After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.

Stock: 4 °C,-20 °C

Stockage commentaire:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: Profilin (PFN)

Autre désignation: Profilin

Sujet:

Inflammatory Profilin

TLR11, an innate sensor for profilin (Toxoplasma gondii), is an intracellular receptor that resides in the endoplasmic reticulum. The 12 membrane-spanning endoplasmic reticulum-resident protein UNC93B1 interacts directly with TLR11 and regulates the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12, a previously uncharacterized TLR, also recognizes profilin from Toxoplasma gondii. TLR12 is sufficient for recognition of profilin by plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both required in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice succumb rapidly to T. gondii infection.

Poids moléculaire: ~20kDa (SDS-PAGE)

UniProt: Q58NA1