DKK3 Protein (AA 23-349) (His tag)

N° du produit ABIN2870735

Cette protéine Recombinant DKK3 est produite dans HEK-293 Cells.

Aperçu rapide pour DKK3 Protein (AA 23-349) (His tag) (ABIN2870735)

Antigène: DKK3

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: >95 % as determined by SDS-PAGE.

Détail du produit

Attributs du protein: AA 23-349

Purification/Conjugué: Cette DKK3 protéine est marqué à la His tag.

Séquence: AA 23-349

Attributs du produit: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.1 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Détail du antigène

Antigène: DKK3

Autre désignation: Dkk-3

Sujet: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Poids moléculaire: 37.1 kDa

NCBI Accession: NP_056629