IgA1 Protéine

N° du produit ABIN3119703

Cette protéine Native IgA1 est produite dans Human.

Aperçu rapide pour IgA1 Protéine (ABIN3119703)

Antigène: IgA1

Type de proteíne: Native

Origine: Humain

Source: Human

Pureté: > 95 %

Détail du produit

Fonction: Immunoglobulin A1, Human Plasma (IgA1)

Attributs du produit: Human plasma-derived IgA.
The predominant IgA subclass in circulation, comprising 90% of total serum IgA. It functions as a pathogen neutralizer, immune complex clearance facilitator, and cytoxicity mediator.

Information d'application

Indications d'application: For use in: IsoC

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3.

Stock: -80 °C

Stockage commentaire: -70°C or lower

Détail du antigène

Antigène: IgA1

Autre désignation: Immunoglobulin A1

Sujet: Serum IgA1 is the predominant subclass of Immunoglobulin A in human circulation, comprising approximately 90% of total serum IgA. It eatures a distinctive hinge region with multiple O-linked glycans, distinguishing it structurally from IgA2. IgA1 serves critical immune functions by neutralizing pathogens, facilitating immune complex clearance, and mediating antibody-dependent cell-mediated cytotoxicity through FcαRI receptors on neutrophils and monocytes.
Aberrant glycosylation of IgA1 plays a central role in IgA nephropathy pathogenesis, where galactose-deficient IgA1 forms immune complexes that deposit in glomeruli, triggering kidney inflammation and damage. Additionally, IgA1 abnormalities are implicated in IgA vasculitis, celiac disease, and certain autoimmune conditions.