ACVA Protein (AA 311-426)

N° du produit ABIN4369364

Détail du produit

Antigène: ACVA (Activin A (ACVA))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 311-426

Origine: Humain

Source: HEK-293 Cells

Marque: ActiveMax®

Séquence: AA 311-426

Attributs du produit: This protein carries no "tag". The protein has a calculated MW of 13 kDa. The protein migrates as 14 kDa under reducing (R) condition, and 27 kDa under non-reducing (NR) condition (SDS-PAGE).

Pureté: >95 % as determined by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 0.1 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.056 % TFA in 60 % ACN

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: No activity loss was observed after storage at: 4-8°C for 1 year in lyophilized state 4-8°C for 1 month under sterile conditions after reconstitution -20°C to -70°C for 3 months under sterile conditions after reconstitution

Référence

Basu, Bhattacharya, Ray, Mukhopadhyay, Chatterjee, Roy: "Invasion of ovarian cancer cells is induced byPITX2-mediated activation of TGF-β and Activin-A." dans: Molecular cancer, Vol. 14, pp. 162, (2015) (PubMed).

Détail du antigène

Antigène: ACVA (Activin A (ACVA))

Autre désignation: Activin A /INHBA (ACVA Produits)

Synonymes: inhibin beta A subunit Protein, Inhba Protein

Sujet: Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various β subunits (βA, βB, βC, and βE in mammals), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. Activin A is a widely expressed homodimer of two βA chains. The βA subunit can also heterodimerize with a βB or βC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human βA chain shares 100 % amino acid sequence identity with bovine, feline, mouse, porcine, and rat βA.

Poids moléculaire: 13.0 kDa

Pathways: Hormone Transport, Peptide Hormone Metabolism