IL1F9 Protéine

N° du produit ABIN5564382

Cette protéine Recombinant IL1F9 est produite dans Escherichia coli (E. coli).

Aperçu rapide pour IL1F9 Protéine (ABIN5564382)

Antigène: IL1F9 (Interleukin 1 Family Member 9 (IL1F9))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Pureté: >95 % (SDS-PAGE)

Détail du produit

Fonction: IL-36gamma (aa 18-169) (human) (rec.) (untagged)

Réactivité croisée: Humain

Attributs du produit: Human IL-36gamma (aa Ser18-Asp169) is untagged.

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: 0.1 mg/mL

Buffer: Contains PBS.

Conseil sur la manipulation: After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.

Stock: 4 °C,-20 °C

Stockage commentaire:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: IL1F9 (Interleukin 1 Family Member 9 (IL1F9))

Autre désignation: IL-36gamma

Sujet:

Interleukin-36gamma Interleukin-1 Family Member 9, IL-1F9

IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells (alphabeta T cells and gammadelta T cells) and keratinocyte proliferation. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. IL-36gamma is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines.

Poids moléculaire: ~17kDa

UniProt: Q9NZH8