LINGO1 Protein (AA 241-337) (His tag)

N° du produit ABIN5854137

Protéine Recombinant LINGO1 exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour LINGO1 Protein (AA 241-337) (His tag) (ABIN5854137)

Antigène: LINGO1 (Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Pureté: > 90 %

Détail du produit

Attributs du protein: AA 241-337

Purification/Conjugué: Cette LINGO1 protéine est marqué à la His tag.

Séquence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSLKVL EISHWPYLDT MTPNCLYGLN LTSLSITHCN LTAVPYLAVR HLVYLRFLNL SYNPISTIEG SMLHELLRLQ EIQLVGGQLA VVEPYAFRGL NYL

Purification: > 90% by SDS-PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Denatured

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 20 mM Tris-HCl buffer ( pH 8.0) containing 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: LINGO1 (Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1))

Autre désignation: LINGO-1

Sujet: Lingo1 also known as Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein1. LINGO-1 is primarily expressed in neuronal tissue, and most abundantly in cortex. It has been implicated in the inhibition of axon regeneration through a ternary complex formed with NgR1 (ligand-binding subunit) and p75 (signal transducing subunit). The inhibitory action is achieved through RhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in the central nervous system. LINGO-1 also inhibits oligodendrocyte precursor differentiation and myelination, by a mechanism that also involves activation of RhoA, but which apparently does not require 75 or NgR1. Recombinant human LINGO1 protein, was expressed in E. coli

Poids moléculaire: 15.1 kDa (133aa)

NCBI Accession: NP_116197