Ganciclovir Protéine

N° du produit ABIN624143

Cette protéine Synthetic Ganciclovir est exprimée dans not_set.

Aperçu rapide pour Ganciclovir Protéine (ABIN624143)

Antigène: Ganciclovir

Type de proteíne: Synthetic

Origine: Synthetic

Hôte: Veuillez nous consulter SVP

Pureté: > 99.0 %.

Détail du produit

Attributs du produit: Ganciclovir

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is recommended to reconstitute the lyophilized Ganciclovir in sterile 18M omega cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stock: 4 °C

Détail du antigène

Antigène: Ganciclovir

Sujet: Ganciclovir is a white to off-white crystalline powder with a molecular formula of C9H13N504 and a molecular weight of 255.23. Introduction: Ganciclovir (GCV) is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research. Ganciclovir is a synthetic analogue of 2'-deoxy-guanosine. It is initially phosphorylated to a deoxyguanosine triphosphate (dGTP) analogue. This mechanism competitively inhibits the integration of dGTP by viral DNA polymerase, resulting in the termination of elongation of viral DNA. Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. The cell cycle is irreversibly arrested at the G2-M checkpoint. Gap junction involvement in the ganciclovir bystander effect has been studied. Ganciclovir has been used to study loss of telomeres and to evaluate sensitivity of viruses to antiviral treatments. Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required. Synonyms: Histone H3-like centromeric protein A, Centromere protein A, CENP-A, Centromere autoantigen A, CENPA.