CD38 Protein (AA 43-300) (Fc Tag)

N° du produit ABIN6253396

Cette protéine Recombinant CD38 est exprimée dans HEK-293 Cells.

Aperçu rapide pour CD38 Protein (AA 43-300) (Fc Tag) (ABIN6253396)

Antigène: CD38

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: >98 % (SDS-PAGE)

Détail du produit

Attributs du protein: AA 43-300

Purification/Conjugué: Cette CD38 protéine est marqué à la Fc Tag.

Fonction: CD38 (human):Fc (human) (rec.)

Specificité: The extracellular domain of human CD38 (aa 43 - 300) is fused to the N-terminus of the Fc region of human IgG1.

Attributs du produit: Protein. The extracellular domain of human CD38 (aa 43 - 300) is fused to the N-terminus of the Fc region of human IgG1. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). CD38, also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications including social amnesia possibly related to autism. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.

niveau d'endotoxine: <5EU/mg protein (LAL test, Lonza).

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Conseil sur la manipulation: Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Détail du antigène

Antigène: CD38

Sujet:

Alternate Names/Synonyms: ADP-ribosyl Cyclase 1, Cyclic ADP-ribose Hydrolase 1, ADPRC 1, T10

Product Description: CD38, also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications including social amnesia possibly related to autism. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.

Poids moléculaire: ~70kDa (SDS-PAGE)

UniProt: P28907