HpARI (AA 17-251) protein (His tag)

N° du produit ABIN6253463

Protéine Recombinant HpARI exprimée dans HEK-293 Cells.

Aperçu rapide pour HpARI (AA 17-251) protein (His tag) (ABIN6253463)

Antigène: HpARI

Type de proteíne: Recombinant

Origine: Humain, Souris

Source: HEK-293 Cells

Pureté: >90 % (SDS-PAGE)

Détail du produit

Attributs du protein: AA 17-251

Purification/Conjugué: His tag

Fonction: HpARI (Alarmin Release Inhibitor) (rec.) (His)

Specificité: Heligmosomoides polygyrus protein HpARI (aa 17-251) is fused at the C-terminus to a His-tag.

Réactivité croisée: Humain, Souris

Attributs du produit: Heligmosomoides polygyrus protein HpARI (aa 17-251) is fused at the C-terminus to a His-tag.

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test).

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: 1 mg/mL

Buffer: Contains PBS.

Conseil sur la manipulation: After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.

Stock: 4 °C,-20 °C

Stockage commentaire:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: HpARI

Sujet:

Heligmosomoides Polygyrus Alarmin Release Inhibitor

HpARI is a protein secreted by the mouse parasite Heligmosomoides polygyrus. The mature protein HpARI, containing three predicted Complement Control Protein (CCP)-like modules (also known as Short Consensus Repeats (SCRs) or sushi-domains), suppresses type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway. During cell damage, HpARI gains access to the nucleus of necrotic cells, where it binds directly to IL-33 and nuclear DNA, preventing secretion and binding of IL-33 to its receptor. HpARI is a new type of reagent to prevent IL-33-mediated pathology.

Poids moléculaire: ~40kDa (SDS-PAGE), ~40 kDa (Monomer) (SEC)