CCL26 is a small cytokine belonging to the CC chemokine family that is also known as thymus and activation regulated chemokine (TARC). This protein is involved in immunoregulatory and inflammatory processes. It is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. CCL26 was expressed in E.coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. Synonyms: Eotaxin-3, IMAC, MIP-4a, MIP-4alpha, SCYA26, TSC-1, Chemokine (C-C motif) ligand 26 CCL 26, CCL26, Chemokine (C C motif) ligand 26, macrophage inflammatory protein 4-alpha, MIP 4a, MIP 4alpha, MIP4a, MIP4alpha, SCYA 26, Small inducible cytokine A26, Small inducible cytokine subfamily A (Cys Cys) member 26, Small inducible cytokine subfamily A member 26, Thymic stroma chemokine 1, TSC 1, TSC1,. NCBI no.: NP_006063
Poids moléculaire
8.5 kDa (72aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)