tau-441 (AA 1-441) protein (His tag)

N° du produit ABIN6809918

Cette protéine Recombinant est produite dans Escherichia coli (E. coli).

Aperçu rapide pour tau-441 (AA 1-441) protein (His tag) (ABIN6809918)

Antigène: tau-441

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: >90 % as determined by reduced SDS-PAGE.

Détail du produit

Attributs du protein: AA 1-441

Purification/Conjugué: His tag

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, 1 mM TCEP, 1 mM EDTA, pH 7.5

Stock: -20 °C

Détail du antigène

Antigène: tau-441

Sujet: Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.

Poids moléculaire: 47.9 kDa

NCBI Accession: NP_005901